BYETTA PACKAGE INSERT PDF

Patient Information Leaflet. Package leaflet: Information for the patient. Byetta 5 micrograms solution for injection in pre-filled pen. Byetta 10 micrograms solution . Learn about BYETTA, the BYETTA Pen. in patients with prior severe hypersensitivity reactions to exenatide or to any of the product components. PRODUCT MONOGRAPH. BYETTA® exenatide injection. µg/mL. mL prefilled pen (60 doses of 5 µg/dose) and. mL prefilled pen.

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Monitor patients on antidiabetic therapy for blood glucose control if niacin nicotinic acid is added or deleted to the medication regimen and adjust dosages as clinically warranted Magnesium Salicylate: Hypoglycemia was not increased when regular-release exenatide injection solution was combined with metformin without a sulfonylurea. Following a single subcutaneous injection, exenatide is released from the suspension microspheres over approximately 10 weeks.

Exenatide leads to a release of insulin only in the presence of elevated glucose concentrations. Some of these events occurred in patients receiving pharmacologic agents known to affect renal function or hydration status, such as angiotensin converting enzyme inhibitors ACE inhibitorsnonsteroidal anti-inflammatory drugs NSAIDsor diuretics. Hold the autoinjector upright with the orange cap toward the ceiling.

Concurrent treatment with prandial insulin has not been studied and cannot be recommended.

Official BYETTA® (exenatide) injection Healthcare Professional Website

The hypoglycemia or hyperglycemia pacoage occurs during octreotide acetate therapy is usually mild, but may result in overt diabetes mellitus or necessitate dose changes in insulin or other hypoglycemic agents. Exenatide may slow gastric emptying.

Hypoglycemia, sometimes resulting in coma, can occur. Exenatide is a amino acid GLP-1 agonist isolated from the salivary gland venom of the lizard Heloderma suspectum Gila monster.

Exenatide has not been found to be directly nephrotoxic in preclinical or clinical studies. Adjust treatment with antidiabetic agents as clinically indicated. Paackage, the use of exenatide is not recommended in patients with severe GI disease e. The Cmax values increased less than proportionally over the same range. Both first- and second-phase insulin secretion improved significantly over placebo in patients with type 2 diabetes.

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Administer twice daily, within the minute time period prior to the morning and evening meals. Moderate Animal inseet indicate that monoamine oxidase inhibitors MAOIs may stimulate insulin secretion. In Februarythe FDA and EMA stated that after reviewing a number of clinical trials and animal studies, the current data does not support an increased risk of pancreatitis and pancreatic cancer in innsert receiving incretin mimetics.

Indapamide can decrease insulin sensitivity thereby leading to glucose intolerance and hyperglycemia. Minor Thyroid hormones are important in the regulation of carbohydrate metabolism, gluconeogenesis, the mobilization of glycogen stores, and protein synthesis.

Patients treated with lanreotide may experience either hypoglycemia or hyperglycemia.

Type 2 Diabetes Medication | BYETTA® (exenatide) injection

Because blood glucose may be lowered by the use of chromium, patients who are on antidiabetic agents may need dose adjustments. Close monitoring of blood glucose is necessary for individuals who use antidiabetic agents whenever there is a change in thyroid treatment.

Moderate Disturbances of blood glucose, including hyperglycemia and hypoglycemia, have been reported in patients treated concomitantly with quinolones and an antidiabetic agent. For treatment of cold symptoms, nasal decongestants may be packate for short term, limited use 1 to 3 days as an alternative to systemic decongestants packahe patients taking medications for diabetes.

Constituents in garlic might have some antidiabetic activity, and may increase serum insulin inserr and increase glycogen storage in the liver. Exenatide extended-release injection suspension Bydureon, Bydureon BCise: Moderate Reserpine may mask the signs and symptoms of hypoglycemia.

Patients with diabetes treated with pegvisomant and antidiabetic agents may be more likely to experience hypoglycemia.

Discontinue the quinolone if a hypoglycemic reaction occurs and initiate appropriate therapy immediately. Blood glucose monitoring is warranted in patients with type 2 diabetes prior to starting and during lorcaserin treatment. Patients should also be aware of the carbohydrate intake provided by certain types of alcohol in the diet, which can contribute to poor glycemic control.

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Tell your healthcare provider if you have severe problems with your stomach, such as delayed emptying of your stomach gastroparesis or problems with digesting food. Major Careful monitoring of blood glucose is recommended when chloroquine and antidiabetic agents, including the incretin mimetics, are coadministered. When possible, it may be prudent to avoid exenatide until data in human indert is available.

Corticosteroids stimulate hepatic glucose production and inhibit peripheral glucose uptake into muscle and fatty tissues, producing insulin resistance. The mean apparent volume of distribution of exenatide following subcutaneous administration of a single dose of exenatide is When added to insulin detemir, a reduction in the dose of insulin detemir may be needed to reduce insfrt the insulin detemir package label recommends a dose of insulin detemir 10 units subcutaneously once daily when combining with a GLP-1 receptor agonist.

Exenatide has also been shown to reduce food intake in both animals and humans, which gyetta help to control weight. Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine: Both hyperglycemia and hypoglycemia have been described in patients treated with acetazolamide.

The mean terminal half-life of the injection solution Unsert is 2. Adequate blood glucose monitoring should be continued and followed.

bystta Exenatide acts to improve glucose control via several mechanisms. Tell your healthcare provider if you have or had kidney problems or a kidney transplant. Patients receiving these drugs concomitantly with antidiabetic agents should be monitored for changes in glycemic control.

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Postmarketing reports of altered renal function have been documented, including increased serum creatinine, renal impairment, worsened chronic renal failure and acute renal failure unspecifiedsometimes requiring hemodialysis or kidney transplantation.

Other oral bgetta may also be considered as possible alternatives in some patients. After use, properly dispose of used pen needles.